锘?!DOCTYPE html> 鍏ㄧ悆鐮斿彂 | 涓浗棣栨锛佸杩堝畞®鐢ㄤ簬娌荤枟鍎跨浣庣骇鍒剳鑳惰川鐦ら€傚簲鐥囪繘鍏II鏈熶复搴奯鍥剧墖鏂伴椈_瀛︽湳鍔ㄦ€乢鐮斿彂鍔ㄦ€乢鐮斿彂鍒涙柊_澶嶆槦鍖昏嵂-鎸佺画鍒涙柊 涔愪韩鍋ュ悍
  • ESG
  • 鎶曡祫鑰呭叧绯?/a>
  • 鏂伴椈涓績
  • 鑱屼笟鍙戝睍
  • 2025-07-09

    鍏ㄧ悆鐮斿彂 | 涓浗棣栨锛佸杩堝畞鐢ㄤ簬娌荤枟鍎跨浣庣骇鍒剳鑳惰川鐦ら€傚簲鐥囪繘鍏II鏈熶复搴?

    7鏈?鏃ワ紝澶嶆槦鍖昏嵂锛?00196.SH锛?2196.HK锛夊甯冿紝鑷富鐮斿彂鐨凪EK1/2閫夋嫨鎬ф姂鍒跺墏澶嶈繄瀹?sup>庐锛堥€氱敤鍚嶏細鑺︽矁缇庢浛灏肩墖锛屼互涓嬬畝绉扳€滆鑽搧鈥濓級鐢ㄤ簬娌荤枟鍎跨浣庣骇鍒剳鑳惰川鐦わ紙pLGG锛夐€傚簲鐥囦簬涓浗澧冨唴锛堜笉鍖呮嫭娓境鍙板湴鍖猴級鍚姩鈪㈡湡涓村簥璇曢獙銆?/span>



    鐜嬪叴鍒╁崥澹?/span>

    澶嶆槦鍖昏嵂鑱斿腑鎬昏銆佸叏鐞冪爺鍙戜腑蹇僀EO


    鈥?/span>

    鎴戜滑闈炲父娆e枩鍦扮湅鍒板杩堝畞鐢ㄤ簬娌荤枟鍎跨浣庣骇鍒剳鑳惰川鐦よ繘鍏II鏈熶复搴婄殑鍏抽敭闃舵锛岃繖涓嶄粎鏄腑鍥介涓繘鍏ヨ棰嗗煙鈪㈡湡涓村簥鐨凪EK闈跺悜鑽墿锛屼篃鏄鏄熷尰鑽叏鐞冪爺鍙戠殑鍙堜竴閲岀▼纰戙€傛湭鏉ワ紝澶嶆槦鍖昏嵂鍏ㄧ悆鐮斿彂鍥㈤槦灏嗛珮鏁堟帹杩涗复搴婅繘绋嬶紝灏芥棭璁╂洿澶氭偅鑰呰幏鐩婁簬杩欎竴鍒涙柊鐤楁硶銆?/span>

    鈥?/span>


    鍎跨浣庣骇鍒兌璐ㄧ槫锛坧LGG锛夋偅鑰呮槸鎸囦綆绾у埆鑴戣兌璐ㄧ槫涓殑骞撮緞锛?8宀佺殑鍎跨鍜岄潚灏戝勾鎮h€咃紝涓旀墍鎮g柧鐥呬负2021骞翠笘鐣屽崼鐢熺粍缁囷紙WHO锛変腑鏋㈢缁忕郴缁熻偪鐦ゅ垎绫讳腑鎵€鐗规寚鐨勫寘鎷効绔ュ瀷寮ユ极鎬т綆绾у埆鑳惰川鐦ゃ€佸眬闄愭€ф槦褰㈢粏鑳炶兌璐ㄧ槫绛夊湪鍐呯柧鐥呰€呫€俻LGG鏄効绔ユ渶甯歌鐨勪腑鏋㈢缁忕郴缁熻偪鐦わ紝鍗犳墍鏈夊効绔ヤ腑鏋㈢缁忕郴缁熻偪鐦ょ殑40-50%銆?015骞寸編鍥芥柊璇婃柇鐨刾LGG鐥呬緥鏁扮害涓?000~1600渚嬶紝鍦ㄤ腑鍥藉皻鏃犳槑纭殑鍎跨浣庣骇鍒兌璐ㄧ槫鍙戠梾鐜囨姤閬撱€?/span>


    鏍规嵁涓€椤瑰涓績銆佸崟鑷傗叀鏈熶复搴婄爺绌舵暟鎹樉绀?/span>[1]锛屽杩堝畞娌荤枟BRAF铻嶅悎绐佸彉鎴朆RAF V600E绐佸彉鎴朜F1绐佸彉闃虫€х殑鍎跨浣庣骇鍒剳鑳惰川鐦ゆ偅鑰呯殑瀹㈣缂撹В鐜囷紙ORR锛夎揪鍒颁簡68.2%锛岀柧鐥呮帶鍒剁巼锛圖CR锛夊彲杈?00%锛屽湪鐮旂┒鏈熼棿鏃犳偅鑰呭嚭鐜扮柧鐥呰繘灞曪紝鎵€鏈夋偅鑰呭潎涓嶅悓绋嬪害鑾风泭銆傛涓村簥鐮旂┒缁撴灉鏄剧ず澶嶈繄瀹?sup>庐瀵逛簬BRAF铻嶅悎绐佸彉鎴朆RAF V600E绐佸彉鎴朜F1绐佸彉闃虫€х殑鍎跨浣庣骇鍒兌璐ㄧ槫鍏锋湁鑹ソ鐨勬不鐤楁晥鏋滐紝瀵逛簬鍎跨浣庣骇鍒兌璐ㄧ槫鐨勬不鐤楁彁渚涗簡闈跺悜娌荤枟鐨勯€夋嫨銆傚杩堝畞鏈夋湜鏀瑰彉pLGG鐨勭幇鏈夋不鐤楁牸灞€锛岃鏇村鎮h€呰幏鐩娿€?/span>


    鎴嚦鐩墠锛屽杩堝畞宸蹭簬涓浗澧冨唴涓婂競骞惰幏鎵逛袱椤归€傚簲鐥囷紝鍖呮嫭鐢ㄤ簬娌荤枟鏈楁牸姹夋柉缁嗚優缁勭粐缁嗚優澧炵敓鐥囷紙LCH锛夊拰缁勭粐缁嗚優鑲跨槫鎴愪汉鎮h€咃紱浠ュ強2宀佸強2宀佷互涓婁即鏈夌棁鐘躲€佹棤娉曟墜鏈殑涓涚姸绁炵粡绾ょ淮鐦わ紙PN锛夌殑鈪犲瀷绁炵粡绾ょ淮鐦ょ梾锛圢F1锛夊効绔ュ強闈掑皯骞存偅鑰呫€?/span>


    澶嶈繄瀹?sup>庐鐢ㄤ簬娌荤枟鎴愪汉鈪犲瀷绁炵粡绾ょ淮鐦ょ梾銆佸効绔ヤ綆绾у埆鑴戣兌璐ㄧ槫浜庝腑鍥藉鍐呭潎澶勪簬鈪㈡湡涓村簥璇曢獙闃舵锛岃鑽搧鐢ㄤ簬娌荤枟棰呭鍔ㄩ潤鑴夌暩褰€佸効绔ユ湕鏍兼眽鏂粏鑳炵粍缁囩粏鑳炲鐢熺棁浜庝腑鍥藉鍐呭潎澶勪簬鈪℃湡涓村簥璇曢獙闃舵銆傚叾涓紝璇ヨ嵂鍝佺敤浜庢棤娉曟墜鏈垨鏈悗娈嬬暀/澶嶅彂鐨凬F1鐩稿叧鐨勪笡鐘剁缁忕氦缁寸槫鎴愪汉鎮h€呫€佸効绔ユ湕鏍兼眽鏂粍缁囩粏鑳炲鐢熺棁涓ら」閫傚簲鐥囧潎宸茶鍥藉鑽搧鐩戠潱绠$悊灞€鑽搧瀹¤瘎涓績绾冲叆绐佺牬鎬ф不鐤楄嵂鐗╃▼搴忋€?/span>


    [1] 1.Wenbin Li, Ying Mao, Zhuang Kang, et al. A phase II study to explore the efficacy and safety of FCN-159 in recurrent or progressive pediatric low-grade glioma (pLGG) with MAPK pathway activation. ESMO LBA 2023.