!DOCTYPE html> 澶嶆槦鍖昏嵂鑷爺鍒涙柊鑽姉PD-1鍗曟姉姹夋柉鐘?#174;娆х洘鑾锋壒涓婂競锛岀敤浜庝竴绾挎不鐤楀箍娉涙湡灏忕粏鑳炶偤鐧?_婊氬姩鏂伴椈_鐮斿彂鍒涙柊_澶嶆槦鍖昏嵂-鎸佺画鍒涙柊 涔愪韩鍋ュ悍
  • ESG
  • 鎶曡祫鑰呭叧绯?/a>
  • 鏂伴椈涓績
  • 鑱屼笟鍙戝睍
  • 2025-02-06

    澶嶆槦鍖昏嵂鑷爺鍒涙柊鑽姉PD-1鍗曟姉姹夋柉鐘?sup>庐娆х洘鑾锋壒涓婂競锛岀敤浜庝竴绾挎不鐤楀箍娉涙湡灏忕粏鑳炶偤鐧?


    姹夋柉鐘?sup style="box-sizing:border-box;">鏄?span style="font-size:16px;box-sizing:border-box;">鍏ㄧ悆棣栦釜鑾锋壒涓€绾挎不鐤桬S-SCLC鐨勬姉PD-1鍗曟姉銆?

    姹夋柉鐘?sup style="box-sizing:border-box;">鏄?span style="font-size:16px;box-sizing:border-box;">棣栦釜涓斿敮涓€鍦ㄦ鐩熻幏鎵逛笂甯傜敤浜嶦S-SCLC娌荤枟鐨勬姉PD-1鍗曟姉銆?

    姹夋柉鐘?sup style="box-sizing:border-box;">鐩墠宸插湪涓浗銆佹娲插拰涓滃崡浜氬涓浗瀹惰幏鎵逛笂甯傦紝鎯犲強瓒呰繃90,000浣嶆偅鑰?/span>銆?


    2025骞?鏈?鏃ワ紝澶嶆槦鍖昏嵂锛?00196.SH锛?2196.HK锛夊甯冿紝鎺ц偂瀛愬叕鍙稿瀹忔眽闇栵紙02696.HK锛夎嚜涓荤爺鍙戠殑鎶桺D-1鍗曟姉鏂瞾鍒╁崟鎶楁敞灏勬恫锛堟鐩熷晢鍝佸悕锛欻etronifly锛屼腑鍥藉鍐呭晢鍝佸悕锛氭眽鏂姸锛夎仈鍚堝崱閾傚拰渚濇墭娉婅嫹鐢ㄤ簬骞挎硾鏈熷皬缁嗚優鑲虹檶锛圗S-SCLC锛夋垚浜烘偅鑰呬竴绾挎不鐤楃殑涓婂競璁稿彲鐢宠锛圡AA锛変簬杩戞棩鑾锋鐩熷鍛樹細锛堝嵆European Commission锛夋壒鍑嗐€傛嵁姝わ紝璇ヨ嵂鍝佽幏寰楁墍鏈夋鐩熸垚鍛樺浗鍙婂啺宀涖€佸垪鏀暒澹櫥鍜屾尓濞侊紙鍒嗗埆涓烘娲茬粡娴庡尯鍥藉锛夌殑闆嗕腑涓婂競璁稿彲锛屽苟鎴愪负棣栦釜涓斿敮涓€鍦ㄦ鐩熸壒鍑嗙敤浜庡箍娉涙湡灏忕粏鑳炶偤鐧岋紙ES-SCLC锛夋不鐤楃殑鎶桺D-1鍗曟姉銆?



    鎴嚦鐩墠锛屾眽鏂姸浜庝腑鍥藉鍐咃紙涓嶅寘鎷腐婢冲彴鍦板尯锛夎幏鎵圭殑閫傚簲鐥囧寘鎷仈鍚堝寲鐤椾竴绾挎不鐤楅碁鐘堕潪灏忕粏鑳炶偤鐧岋紙NSCLC锛夈€佸箍娉涙湡灏忕粏鑳炶偤鐧岋紙ES-SCLC锛夈€侀绠¢碁鐘剁粏鑳炵檶锛圗SCC锛夊強闈為碁鐘堕潪灏忕粏鑳炶偤鐧岋紙nsNSCLC锛夛紱浜﹀凡鍒嗗埆浜庢鐩熴€佸嵃搴﹀凹 瑗夸簹銆佹煬鍩斿銆佹嘲鍥借幏鎵逛笂甯傘€傛澶栵紝鍙︽湁浠ユ眽鏂姸涓烘牳蹇冪殑澶氶」鑱斿悎鐤楁硶姝e湪鍏ㄧ悆澶氫釜鍥藉鍜屽湴鍖哄紑灞曚复搴婅瘯楠屻€?


    姹夋柉鐘?sup>庐鏄叏鐞冮涓幏鎵逛竴绾挎不鐤楀皬缁嗚優鑲虹檶鐨凱D-1鎶戝埗鍓傘€?浠ヤ复搴婇渶姹備负瀵煎悜锛屽瀹忔眽闇栧氨H鑽繘琛屼簡宸紓鍖栥€佸缁村害甯冨眬锛岃仛鐒﹁偤鐧屻€佹秷鍖栭亾鑲跨槫绛夐珮鍙戝ぇ鐧岀锛屽湪鍏ㄧ悆鑼冨洿鍐呯疮璁″叆缁勯€?800鍚嶅彈璇曡€呫€?2023骞达紝澶嶅畯姹夐湒涓嶪ntas杈炬垚鍚堜綔锛屾巿鏉冨叾H鑽湪娆ф床鍜屽嵃搴﹀叡50澶氫釜鍥藉鐨勭嫭瀹跺紑鍙戝拰鍟嗕笟鍖栨潈鐩娿€傛湰娆¤幏鎵硅鐩栨鐩熷叏閮?7涓垚鍛樺浗浠ュ強娆ф床缁忔祹鍖哄浗瀹舵尓濞併€佸啺宀涘拰鍒楁敮鏁﹀+鐧伙紝璇ュ尯鍩熺殑鍟嗕笟鍖栧皢鐢盜ntas瀛愬叕鍙窤ccord璐熻矗銆?


    澶嶆槦鍖昏嵂浣滀负涓€瀹舵鏍逛腑鍥姐€佸垱鏂伴┍鍔ㄧ殑鍏ㄧ悆鍖栧尰鑽仴搴蜂骇涓氶泦鍥紝鍧氭寔鍒涙柊椹卞姩锛屽洿缁曟湭琚弧瓒崇殑涓村簥闇€姹傦紝閲嶇偣寮哄寲鎶椾綋/ADC銆佺粏鑳炴不鐤椼€佸皬鍒嗗瓙绛夋牳蹇冩妧鏈钩鍙般€備綔涓哄鏄熷尰鑽噸瑕佺殑鎶椾綋鎶€鏈钩鍙帮紝澶嶅畯姹夐湒鍦ㄧ敓鐗╁埗鑽鍩熸寔缁繁鍖栧垱鏂扮爺鍙戙€佷笉鏂墿灞曞鍐呭甯傚満銆佽繘涓€姝ュ寮哄叏鐞冪珵浜夊姏锛屽疄鐜伴珮璐ㄩ噺鍙戝睍銆傛湰娆℃眽鏂姸娆х洘鑾锋壒锛屾爣蹇楃潃澶嶆槦鍖昏嵂鍦ㄥ叏鐞冨垱鏂拌嵂鐗╃爺鍙戝拰鍟嗕笟鍖栨柟闈㈣繄鍑轰簡閲嶈涓€姝ワ紝灏嗚繘涓€姝ユ嫇灞曡鑽搧鐨勫叏鐞冨競鍦哄尯鍩熻幏鎵癸紝鏈夋湜涓哄叏鐞冭偤鐧屾偅鑰呮彁渚涙柊鐨勬不鐤楅€夋嫨銆?

    01

    绐佺牬鍒涙柊锛岃仛鐒︽湭灏戒复搴婇渶姹?br style="box-sizing:border-box;" />

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    鏈H鑽幏EC鎵瑰噯涓昏鍩轰簬ASTRUM-005鐮旂┒锛孉STRUM-005鐮旂┒鏄竴椤归殢鏈恒€佸弻鐩层€佸畨鎱板墏瀵圭収鐨勫浗闄呭涓績III鏈熺爺绌讹紝鏃ㄥ湪璇勪及鏂瞾鍒╁崟鎶楄仈鍚堝寲鐤楀姣斿畨鎱板墏鑱斿悎鍖栫枟鐢ㄤ簬ES-SCLC涓€绾挎不鐤楃殑鐤楁晥鍜屽畨鍏ㄦ€с€?璇ヨ瘯楠屽湪涓浗銆佹鐩熸尝鍏般€佸湡鑰冲叾銆佹牸椴佸悏浜氱瓑澶氫釜鍥藉鍏卞紑璁?28涓瘯楠屼腑蹇冿紝鍏ョ粍585渚嬪彈璇曡€咃紝鍏朵腑绾?1.5%涓虹櫧浜恒€?ASTRUM-005涓村簥璇曢獙缁撴灉浜?022骞寸編鍥戒复搴婅偪鐦ゅ浼氾紙ASCO锛夊勾浼氫互鍙eご鎶ュ憡鏂瑰紡棣栨鍙戝竷锛屽苟浜庡叏鐞冨洓澶ч《绾у尰瀛︽湡鍒婁箣涓€鐨勩€婄編鍥藉尰瀛︿細鏉傚織銆嬶紙JAMA锛夊彂琛紝鎴愪负鍏ㄧ悆棣栦釜鐧讳笂JAMA涓诲垔鐨凷CLC鍏嶇柅娌荤枟涓村簥鐮旂┒銆?鍩轰簬ASTRUM-005鐮旂┒锛孒鑽凡闄嗙画鍦ㄤ腑鍥姐€佷笢鍗椾簹澶氬浗鍜屾鐩熻幏鎵圭敤浜庝竴绾挎不鐤桬S-SCLC锛屾垚涓哄叏鐞冮涓幏鎵逛竴绾挎不鐤楀皬缁嗚優鑲虹檶鐨勬姉PD-1鍗曟姉銆?姝ゅ锛屼竴椤笻鑽姣斾竴绾挎爣鍑嗘不鐤楅樋鏇垮埄鐝犲崟鎶楃敤浜嶦S-SCLC鐨勫ご瀵瑰ご妗ユ帴璇曢獙姝e湪缇庡浗寮€灞曪紝浠ヨ繘涓€姝ユ敮鎸丠鑽湪缇庡浗鐨勪笂甯傜敵鎶ャ€?


    02

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    [1] Bray F銆丩aversanne M銆丼ung H 绛変汉銆?022 骞村叏鐞冪檶鐥囩粺璁℃暟鎹細GLOBOCAN 浼拌鍏ㄧ悆 185 涓浗瀹?鍦板尯 36 绉嶇檶鐥囩殑鍙戠梾鐜囧拰姝讳骸鐜囥€侰A 鐧岀棁 J Clin銆?024;74(3):229-263.doi锛?0.3322/caac.21834

    [2] Dingemans AC锛?Fr眉h M锛?Ardizzoni A锛?et al.灏忕粏鑳炶偤鐧岋細ESMO 涓村簥瀹炶返鎸囧崡锛岀敤浜庤瘖鏂€佹不鐤楀拰闅忚鈽嗐€傚畨路鏄傜灏斻€?021;32(7):839-853.doi锛?0.1016/j.annonc.2021.03.207