ISSVA 2026 | 澶嶆槦鍖昏嵂鍒涙柊鑽杩堝畞®涓洪澶朅VM鎮ｈ€呭甫鏉ラ澏鍚戞不鐤楁柊甯屾湜_瀛︽湳鍔ㄦ€乢鐮斿彂鍔ㄦ€乢鐮斿彂鍒涙柊

2026-05-26

ISSVA 2026 | 澶嶆槦鍖昏嵂鍒涙柊鑽杩堝畞^庐涓洪澶朅VM鎮ｈ€呭甫鏉ラ澏鍚戞不鐤楁柊甯屾湜

杩戞棩锛屽浗闄呰剦绠℃€х柧鐥呯爺绌跺浼氾紙ISSVA锛夊ぇ浼氫簬缇庡浗璐瑰煄闅嗛噸鍙紑銆傚鏄熷尰鑽嚜涓荤爺鍙戠殑MEK1/2鎶戝埗鍓傝姦娌冪編鏇垮凹锛堜腑鍥藉鍐呭晢鍝佸悕锛氬杩堝畞^庐锛夋不鐤楁垚浜洪澶栧姩闈欒剦鐣稿舰锛圓VM锛夌殑II鏈熶复搴婄爺绌舵暟鎹紝鍏ラ€塈SSVA澶т細娴锋姤灞曠ず銆傛湰鐮旂┒鐢变笂娴蜂氦閫氬ぇ瀛﹀尰瀛﹂櫌闄勫睘绗節浜烘皯鍖婚櫌鏋楁檽鏇︽暀鎺堢壍澶村紑灞曘€傜爺绌剁粨鏋滄樉绀猴紝鑺︽矁缇庢浛灏煎湪棰呭AVM鎴愪汉鎮ｈ€呬腑鍩轰簬DSA璇勪及鐨勫瑙傜紦瑙ｇ巼杈?4.3%锛?5% CI 35.1鈥?7.2锛夛紝鍏朵腑35.7%杈惧埌娣卞害缂撹В锛堢梾鐏剁缉灏忊墺50%锛夛紝瀹夊叏鎬х壒寰佹棦寰€鎶ラ亾涓€鑷翠笖鍙鐞嗐€傝繖涓€鎴愭灉鏄姦娌冪編鏇垮凹浠庣綍瑙佽偪鐦ら鍩熷悜琛€绠＄暩褰㈡不鐤楁嫇灞曠殑閲嶈鎺㈢储锛屼害鏄绠＄嚎鍦ㄧ簿鍑嗘不鐤楄竟鐣屼笂鐨勫張涓€杩涘睍銆?

鐮旂┒鑳屾櫙

棰呭鍔ㄩ潤鑴夌暩褰紙AVM锛夋槸涓€绫荤綍瑙併€佽繘灞曟€х殑楂樻祦閲忚绠＄暩褰紝涓昏鐢卞姩鑴変笌闈欒剦涔嬮棿寮傚父鐩存帴浜ら€氭墍鑷淬€傛偅鑰呭彲鍑虹幇鐤肩棝銆佸嚭琛€銆佹簝鐤°€佸姛鑳藉彈闄愬強澶栬姣佹崯绛夎〃鐜帮紝涓ラ噸褰卞搷鐢熸椿璐ㄩ噺锛岄儴鍒嗘偅鑰呯敋鑷冲彲鍑虹幇鍗卞強鐢熷懡鐨勫苟鍙戠棁銆傜洰鍓嶅叏鐞冨皻鏃犵敤浜嶢VM鐨勮嵂鐗╄幏鎵癸紝涓村簥娌荤枟渚濊禆鎵嬫湳鍒囬櫎鍜屼粙鍏ユ爴濉炪€傜劧鑰岋紝鎵嬫湳瀹屽叏鍒囬櫎鐜囦綆銆佸鍙戠巼楂橈紝瀵逛簬鏃犳硶鎵嬫湳鎴栧弽澶嶅鍙戠殑鎮ｈ€咃紝浠嶅瓨鍦ㄦ槑纭湭婊¤冻鐨勪复搴婇渶姹傘€傝姦娌冪編鏇垮凹鏄竴绉嶉珮閫夋嫨鎬EK1/2鍙ｆ湇鎶戝埗鍓傦紝鍙姂鍒禦AS-MAPK淇″彿閫氳矾锛屼负闈跺悜娌荤枟AVM鎻愪緵鏈哄埗鍩虹銆傛湰娆″叕甯冪殑鍗曡噦銆佸紑鏀炬爣绛綢I鏈熺爺绌讹紙CTR20222381锛夋棬鍦ㄨ瘎浼板叾鍦ㄩ澶朅VM鎴愪汉鎮ｈ€呬腑鐨勭枟鏁堜笌瀹夊叏鎬с€?

鐮旂┒璁捐

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鐤楁晥鏁版嵁

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鍥?1.鍩轰簬DSA璇勪及鐨勯澏鐥呯伓澶у皬鐩稿浜庡熀绾跨殑鏈€浣冲彉鍖栫櫨鍒嗙巼鐎戝竷鍥?

瀹夊叏鎬х壒寰佸彲鎺у彲绠＄悊

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琛?锛氫笉鑹簨浠舵眹鎬昏〃

缁撹

鑺︽矁缇庢浛灏煎湪棰呭AVM鐨処I鏈熺爺绌朵腑鏄剧ず鍑哄垵姝ョ枟鏁堝拰鍙鐞嗙殑瀹夊叏鎬с€傚熀浜嶥SA璇勪及鐨凮RR涓?4.3%锛屾繁搴︾紦瑙ｇ巼涓?5.7%锛屽苟鍦∕RI璇勪及涓瀵熷埌鐩镐技鐨勬€讳綋鐤楁晥瓒嬪娍銆傛湰鐮旂┒涓洪澶朅VM鑽墿娌荤枟鐨勮繘涓€姝ユ帰绱笌寮€鍙戞彁渚涗簡鍒濇鐨勪复搴婅瘉鎹€?

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鍙傝€冩枃鐚細

1. Chen Hua, et al. Efficacy and Safety of Luvometinib, a MEK1/2 Inhibitor in Patients with Extracranial Arteriovenous Malformations: A Phase II Study. Presented at: 聽ISSVA World Congress 2026; May 19-22, 2026. Abstract 146.

鏈潗鏂欎负涓撲笟鍖诲璧勬枡锛屼粎渚涘尰鐤楀崼鐢熶笓涓氫汉澹弬鑰冿紝涓嶆瀯鎴愪换浣曟不鐤楀缓璁€?

鑱旂郴鏂瑰紡